British Air Force Typhoon fighter aircraft have operated alongside French warplanes in a joint strike against an hidden munitions depot in Syria employed by the IS group, as stated by the UK's MoD.
The site, located using surveillance, was thought to be containing munitions and bombs, the release indicated, and was positioned in mountains just above the ancient city of Palmyra in Syria's central region.
"Our fighter planes used laser-guided Paveway IV weapons to strike a series of entry passages leading to the depot... initial indications indicate the strike was effective," the MoD said.
There was no evidence of any civilian impact in the attack late on Saturday and each participating jet returned to base without incident, the defence officials confirmed.
The Typhoon FGR4s were supported by a Voyager tanker plane.
The Islamic State group - alternatively referred to as ISIS - imposed militant control over significant areas in both Syria and Iraq until 2019.
"This strike demonstrates the UK's leading role, and determination to work closely with allied nations, to stamp out any re-emergence of the terrorist group and their violent and radical beliefs in the area," UK Defence Secretary the Defence Secretary said.
British military aircraft have performed patrols over Syria to "prevent any attempted comeback" of IS after its routing at the climactic battle in Baghuz in 2019, the authorities noted.
"I must thank all the members of the UK armed forces involved in this mission for their expertise and their valour," Healey said. "They were among numerous British troops on duty over the holidays. This operation, to eliminate dangerous terrorists who threaten our safety, shows how British military are ready to step up, continuously, ensuring Britain's security within its borders and powerful internationally."
Last December, the United States armed forces carried out what it called a "major assault" targeting IS targets in Syria, subsequent to an attack killed two American soldiers and a civilian linguist in Palmyra.
The United Nations reports IS still maintains an estimated 5,000 to 7,000 militants in Syria and Iraq.